Kosuke M. Teshima

Research Associate
Graduate University for Advanced Studies
Hayama, Kanagawa 240-0193, Japan
Phone: +81-46-858-1576
Fax: +81-46-858-1544
E-mail: kteshima

soken.ac.jp

CV (PDF)

2006- Research Associate, Graduate University for Advanced Studies, Advisor: Dr. H. Innan
2005-2006, Research Associate, University of Chicago, Advisor: Dr. M. Przeworski
2004-2005, Research Associate, Brown University, Advisor: Dr. M. Przeworski
2002-2004, Research Associate, University of Cincinnati, Advisor: Dr. R. Chakraborti
1997-2002, Ph.D., University of Tokyo. Advisor: Dr. F. Tajima

Research Interests

Simulating genome evolution . The history of organisms is just a single representation from many possible scenarios. By developing simulation programs, I'd like to understand the evolutionary mechanisms behind the actual history of genome evolution.

Understanding the evolutionary mechanisms of copy number polymorphism . There are many reports that copu number polymorphism relates to many biologically interesting phenotypes. By considering the evolutionary process of the copy number variation, I would like to connent the genetic variation and phenotypic variation. Especially, I'm interested in understanding the evolutionary process of duplicated genes with intergenic gene conversion because gene duplication can provide both advantageous (evolution) and deleterious (genetic disorder) effects.

Publications

Takahashi Y, Teshima KM, Yokoi S, Innan H, Shimamoto K (2009)
Variations in Hd1 proteins, Hd3a promoters, and Ehd1 expression levels contribute to diversity of flowering time in cultivated rice.
Proc Natl Acad Sci USA 106: 4555-4560.

Blekhman R, Man O, Herrmann L, Boyko AR, Indap A, Kosiol C, Bustamante CD, Teshima KM, Przeworski M (2008)
Natural selection on Genes that underlie human disease susceptibility
Curr Biol 18: 883-889.

Teshima KM, Innan H (2008)
Neofunctionalization of duplicated genes under the pressure of gene conversion
Genetics 178: 1385-1398.

Teshima KM, Coop G, Przeworski M (2006)
How reliable are empirical genomic scans for selective sweeps?
Genome Res 16: 702-712.

Teshima KM, Przeworski M (2006)
Directional positive selection on an allele of arbitrary dominance.
Genetics 172: 713-718.

Teshima KM, Innan H (2004)
The effect of gene conversion on the divergence between duplicated genes.
Genetics 166: 1533-1560.

Teshima KM, Tajima F (2002)
The effect of migrarion during the divergence.
Theor Popl Biol 62: 81-95.